For Further Information Please Contact

Head Department of Biotechnology, 
Central Leather Research Institute
Adyar, Chennai - 600 020, India 
Tel: (Off) 044-24430273 
Fax: 91-44-24911589 
Email : mkgowthaman@clri.res.in

Patents / Technology

Inventions

  1. A process for the production of immobilized pancreatic enzyme product for use in leather manufacture
    R. Puvanakrishnan , S.M. Bose and S.C. Dhar
    Indian Patent No.151088 (1980)
  2. A new process for the bating of skins and hides by the use of immobilized pancreatic enzyme product for the manufacture of different types of leather
    R. Puvanakrishnan , S.M. Bose and S.C. Dhar
    Indian Patent No.151089 (1980)
  3. A process for the preparation of a terminally protected tetrapeptide derivative exhibiting in vitro inhibition of platelet aggregation and antimicrobial activity
    C.V. Ramesh, R. Jayakumar, N.R. Kamini and R. Puvanakrishnan
    Indian Patent No.185761 Granted November 2001.

    This invention relates to the synthesis of a novel tetrapeptide derivative (PEP1261) by solution phase strategy and its physicochemical characterization. The tetrapeptide derivative, in the aggregated state, produces inhibitory effect on platelet aggregation. This derivative is evaluated for its optimal cardioprotection in a rat model of myocardial necrosis induced by isoproterenol. HCl. In addition, this peptide derivative exhibits antiarthritic as well as antimicrobial activity. The unique action of this peptide derivative might be useful in the development of potent antithrombotic and antiarthritic drugs.
  4. A process for the synthesis of a novel dipeptide derivative exhibiting in vitro fibrinolytic activity
    C.V. Ramesh, R. Jayakumar and R. Puvanakrishnan
    Indian Patent No.185766 Granted November 2001

    A novel dipeptide derivative expressing in vitro antithrombotic activity is synthesized and its physicochemical properties are extensively characterized. This peptide is tested for induction of tissue-plasminogen activator release in a rat model, measured ex vivo and for its fibrinolytic activity, as determined by in vitro clot lysis. This dipeptide derivative has great potential as a thrombolytic drug.
  5. A process for the production of a novel lipase.
    C.Hemachander, R.Boopathy Naidu and R.Puvanakrishnan
    Indian Patent No.1555 DEL 99

    This invention relates to the production of a potent bacterial lipase from Ralstonia pickettii . A new R.pickettii strain secreting lipases is isolated from soil and the growth medium is standardized. The characteristics of this bacterial lipase are extensively studied and the production is routed through submerged culture fermentation. Application of this lipase is shown in degreasing of woolly sheep skins, as an additive in laundry formulations and in hydrolysis of oils.
  6. An improved process for the production of stable lipase.
    N.R.Kamini, J.Geraldine Sandana Mala, D.Raghunatha Rao and R.Puvanakrishnan
    Indian Patent No. 1556 DEL 99

    This invention relates to the production of a potent fungal lipase from Aspergillus niger . An A.niger strain secreting lipases is isolated from milk and the growth medium is standardized. The physicochemical characterization of this fungal lipase is extensively carried out and the production is standardized via solid state fermentation. Application of this lipase is shown as an additive in detergent formulations and in hydrolysis of oils.
  7. A process for the preparation of alkaline protease and its eco-friendly application in the pretanning processes of leather manufacture.
    CLRI – NCL Joint Patent
    Indian Patent Application No. 159 DEL 2002

  8. US Patent
A process for the preparation of alkaline protease
CLRI – NCL Joint Patent
Application No. 10/095428 (2002)

Research Monograph on
“Enzyme Technology in Beamhouse Practice”
by
R.Puvanakrishnan and S.C.Dhar

This 180 pages book comprises 10 chapters, tracing the important aspects of enzymology, immobilized enzymes and use of enzymes in the pretanning operations viz. soaking, dehairing, bating and degreasing. It has been published by the National Information Centre for Leather and Allied Industries (NICLAI), CLRI, Madras in 1988 and is a Reference Source for B.Tech and M.Tech courses of Anna University, Chennai and Punjab University.

For Further Information Please Contact

Head Department of Biotechnology, 
Central Leather Research Institute
Adyar, Chennai - 600 020, India 
Tel: (Off) 044-24430273 
Fax: 91-44-24911589 
Email : mkgowthaman@clri.res.in