CLRI

List of Peer Reviewed International Publications

Jayamani J, Reddy RR, Madhan B, Shanmugam G (2017). Disintegration of collagen fibrils by Glucono-δ-lactone: An implied lead for disintegration of fibrosis, International Journal of Biological Macromolecules.
Perumal RK, Perumal S, Ramar T, Gopinath A, Ramadass SK, Madhan B, Sivasubramanian S (2017). Collagen-fucoidan blend film with the potential to induce fibroblast proliferation for regenerative applications, International Journal of Biological Macromolecules.
Sivasubramanian S, Chandrasekar G, Akusjarvi SS, Ramar T, Sathuvan M, Kumar RBS, Hussein H, Vincent S, Madhan B, Gunasekaran P, Kitambi SS (2017). Phenotypic Screening Identifies Synergistically Acting Natural Product Enhancing the Performance of Biomaterial Based Wound Healing, Frontiers in Pharmacology, 8.
Masilamani D, Srinivasan V, Ramachandran RK, Gopinath A, Madhan B, Saravanan P (2017). Sustainable Packaging Materials from Tannery trimming solid waste: A new paradigm in wealth from waste approaches. Journal of Cleaner Production, 164,885-891.
Gopinath A, Shanmugam G, Madhan B, Rao JR (2017). Differential precipitation behavior of native and denatured collagen in the presence of alcoholic solvents: A gateway to instant structural analysis. International Journal of Biological Macromolecules, 102,1156-1165.
Sathuvan M, Ramar T, Mani G, Vivek R, Balasubramanian S, Nagaraj S, Gunasekaran P, Madhan B, Rengasamy R (2017). Κ-carrageenan: An effective drug carrier to deliver curcumin to cancer cells and to enhance apoptosis. Carbohydrate Polymers, 160,184-193.
Mohammad SA, Panda R, Madhan B, Demessie BA (2017). Extraction of bio-active compounds from Ethiopian plant material Rumex abyssinicus (mekmeko) root – A study on kinetics, optimization, antioxidant and antibacterial activity. Journal of the Taiwan Institute of Chemical Engineers, 75,228-239.
Kandhasamy S, Perumal S, Madhan B, Maheshwari U, Banday JA, Perumal PT, Santhanakrishnan VP (2017). Synthesis and Fabrication of Collagen Coated Ostholamide Electrospun Nanofiber Scaffold for Wound Healing. ACS Applied Materials and Interfaces, 9(10).
Hussein M, Ramadass SK, Madhan B, Rao JR (2017). Enzymatic Hydrolysis of Limed Trimmings: Preparation, Characterization and Applications of Collagen Hydrolyaste. Journal of the American Leather Chemists Associations, 112(2), 44-51.
Kakkar P, Madhan B, Shanmugam G (2016). Transient structures of keratins from hoof and horn influence their self association and supramolecular assemblies. International Journal of Biological Macromolecules, 93, 172-178.
Sathish, M., Silambarasan, S, Madhan B., & Rao, J. R. (2016). Exploration of GSK'S solvent selection guide in leather industry: a CSIR-CLRI tool for sustainable leather manufacturing. Green Chemistry.
Mohammed S A, Madhan B, Demissie, B. A., Velappan, B., & Selvi, A. T. (2016). Rumex abyssinicus (mekmeko) Ethiopian plant material for preservation of goat skins: approach for cleaner leather manufacture. Journal of Cleaner Production.
Ramadass S K, Jabaris S L, Perumal R K, HairulIslam V I, Gopinath A, Madhan B. (2016). Type I collagen and its daughter peptides for targeting mucosal healing in ulcerative colitis: A new treatment strategy. European J Pharmaceutical Sciences.
Masilamani D, Madhan B., Shanmugam, G., Palanivel, S., & Narayan, B. (2016). Extraction of collagen from raw trimming wastes of tannery: a waste to wealth approach. Journal of Cleaner Production, 113, 338-344.
Tiku M, Madhan B. (2016) Preserving the longevity of long-lived type II collagen and its implication for cartilage therapeutics. Ageing Res Rev. 28, 62-71.
Kakkar P, Madhan B. (2016) Fabrication of keratin-silica hydrogel for biomedical applications. Mater Sci Engg C
Sathish M, Madhan B, Sreeram K J, Rao J R, Nair B U (2016) Alternative carrier medium for sustainable leather manufacturing–a review and perspective, Journal of Cleaner Production, 112(1), 49-58.
Reddy R.R, PhaniKumar B V N, Shanmugam G, Madhan B, Mandal A B. (2015) Molecular Level Insights on Collagen–Polyphenols Interaction Using Spin–Relaxation and Saturation Transfer Difference NMR. The Journal of Physical Chemistry B 119 (44), 14076-14085.
Xiao J, Sun X, Madhan B, Brodsky B, Baum J (2015) NMR studies demonstrate a unique AAB composition and chain register for a heterotrimeric type IV collagen model peptide containing a natural interruption site, Journal of Biological Chemistry 290, 24201-24209.
Saravanan M S, Jayamani J, Shanmugam G, Madhan B. (2015) High concentration of propanol does not significantly alter the triple helical structure of Type I collagen. Coll. and Poly. Sci. 293, 2655-2662.
Natarajan V, Madhan B*, Tiku M L. (2015) Intra-articular Injections of Polyphenols Protect Articular Cartilage from Inflammation-Induced Degradation: Suggesting a Potential Role in Cartilage Therapeutics, PloS One Vol. 10, Issue. 6.
Perumal S, Ramadass SK, Gopinath A Madhan B*, Shanmugam G, Rajadas J, Mandal AB. (2015) Altering the Concentration of Silica Tunes the Functional Properties of Collagen-Silica Composite Scaffolds to Suit Various Clinical Requirements. J Mech Behav Biomed Mater. DOI: 10.1016/ j.jmbbm. 2015.04.006.
Ramadass SK, Anantharaman NV, Subramanian S, Sivasubramanian S, Madhan B*. (2015) Paclitaxel/Epigallocatechin gallate coloaded Liposome: A Synergistic Delivery to Control the Invasiveness of MDA-MB-231 Breast Cancer Cells. Colloids Surf., B. 125, 65-72.
Aravindhan R, Madhan B, Rao JR. (2015) Studies on tara-phosphonium combination tannage: Approach towards a metal free eco-benign tanning system. J Am Leather Chem Assoc., 110, 80-87.
Perumal S, Dubey K, Badhwar R, George KJ, Sharma RK, Bagler G, Madhan B*, Kar K. (2015) Capsaicin inhibits collagen fibril formation and increases the stability of collagen fibers. Eur Biophys J. 44(1-2), 69-76.
Gopinath A, SMM Reddy, Madhan B*, Shanmguam G, Rao JR. (2014) Effect of aqueous ethanol on the triple helical structure of collagen. Eur Biophys J.; 43 (12), 643-652.
Kakkar P, Madhan B, Shanmugam G. (2014) Extraction and characterization of keratin from bovine hoof: a potential material for biomedical applications. SpringerPlus. 3(1):1-9.
Kakkar P, Verma S, Manjubala I, Madhan B.(2014) Development of Keratin-Chitosan-Gelatin composite scaffold for soft tissue engineering. Materials Science and Engineering: C. 12/1;45:343-7.
Ramadass SK, Perumal S, Gopinath A, Nisal A, Subramanian S, Madhan B. (2014) Sol–Gel Assisted Fabrication of Collagen Hydrolysate Composite Scaffold: A Novel Therapeutic Alternative to the Traditional Collagen Scaffold. ACS applied materials & interfaces. N6(17):15015-25.
Shanmugam G, Reddy SMM, Madhan B, Rao JR.(2014) Method of addition of acetonitrile influences the structure and stability of collagen. Process Biochemistry. 49(2):210-6.
Satiesh Kumar R, Sathiamurthi P, Madhan B. (2013) Sol–gel processed mupirocin silica microspheres loaded collagen scaffold: A synergistic bio-composite for wound healing, European Journal of Pharmaceutical Sciences. 52: 104-110.
Sathish M, Madhan B, Saravanan P. (2013) Dry ice - an eco-friendly alternative for ammonium reduction in leather manufacturing. Journal of Cleaner Production. 54:289-295.
Satiesh Kumar R, Sathiamurthi P, Sugin Lal J, Madhan B. (2013) Preparation and evaluation of mesalamine collagen in situ rectal gel: A novel therapeutic approach for treating ulcerative colitis. European Journal of Pharmaceutical Sciences. 48(12):104-110.
Ganesh S, Samala Murali Mohan Reddy, Natarajan V, Madhan B. (2013) 2,2,2-Trifluoroethanol disrupts the triple helical structure and self-association of type I collagen. International Journal of Biological Macromolecules. 54:155-159.
Vasagam SN, Madhan B, Chandrasekaran B, Rao JR. (2013) Studies on selective defect identification of crust leathers for computer-aided grading. J Am Leather Chem Assoc. 108(6), 210-20.
Tamil Selvi A, Aravindhan R, Madhan B. (2013) Studies on the application of natural dye extract from Bixa orellana seeds for dyeing and finishing of leather. Industrial Crops and Products. 43(84):84-86.
Natarajan V, Krithica N, Madhan B. (2013) Preparation and properties of tannic acid cross-linked collagen scaffold and its application in wound healing. Journal of Biomedical Materials Research Part B-Applied. 101B(4):560-567.
Natarajan V, Saravanakumar P, Madhan B. (2012) Collagen adsorption on quercetin loaded polycaprolactone microspheres: Approach for "stealth" implant. International Journal of Biological Macromolecules. 50(4):1091-4.
Krithica N, Natarajan V, Madhan B, Sehgal PK, Mandal AB. (2012) Type I Collagen Immobilized Poly(caprolactone) Nanofibers: Characterization of Surface Modification and Growth of Fibroblasts. Advanced Engineering Materials. 14(4):B149-B54.
Selvi AT, Anjugam E, Devi RA, Madhan B, Kannappan S,.Chandrasekaran B. (2012) Isolation and characterization of bacteria from tannery effluent treatment plant and their tolerance to heavy metals and antibiotics. Asian J. Exp. Biol. Sci. 3(1), 34-41.
Jariashvili K, Madhan B, Brodsky B, Kuchava A, Namicheishvili L, Metreveli N. (2012) Uv damage of collagen: Insights from model collagen peptides. Biopolymers. 97(3):189-98.
Xiao JX, Madhan B, Li YJ, Brodsky B, Baum J. (2011) Osteogenesis Imperfecta Model Peptides: Incorporation of Residues Replacing Gly within a Triple Helix Achieved by Renucleation and Local Flexibility. Biophysical Journal. 101(2):449-58.
Natarajan V, Krithica N, Madhan B, Sehgal PK. (2011) Formulation and Evaluation of Quercetin Polycaprolactone Microspheres for the Treatment of Rheumatoid Arthritis. Journal of Pharmaceutical Sciences. 100(1):195-205.
Musa AE, Selvi AT, Aravindhan R, Madhan B, Fathima A, Rao JR. (2011) Evaluation of Antimicrobial Activity of Lawsonia Inermis (Henna) against Microbial Strains Isolated from Goat Skin/Leather. Journal of the American Leather Chemists Association. 106(5):170-5.
Musa AE, Madhan B, Aravindhan R, Kanth SV, Rao JR, Chandrasekaran B, (2011) Studies on the Henna-Glutaraldehyde Combination Tanning System. Journal of the American Leather Chemists Association. 106(3):92-101.
Musa AE, Aravindhan R, Madhan B, Rao JR, Chandrasekaran B. (2011)Henna-Aluminum Combination Tannage: a Greener Alternative Tanning System. Journal of the American Leather Chemists Association. 106(6):190-9.
Musa AE, Madhan B, Kanth SV, Rao JR, Chandrasekaran B, Gasmelseed GA. (2010) Cleaner tanning process for the manufacture of upper leathers. Clean Technologies and Environmental Policy. 12(4):381-8
Madhan B, Rao JR, Nair BU. (2010) Studies on the Removal of Inter-Fibrillary Materials Part I: Removal of Protein, Proteoglycan, Glycosoaminoglycans from Conventional Beamhouse Process. Journal of the American Leather Chemists Association. 105(5):145-9.
Madhan B, Dineshkumar M, Rao JR, Nair BU. (2010) Studies on the Removal of Inter-Fibrillary Materials Part Removal of Protein) Proteoglycan and Glycosoaminoglycans from Biobased Pre-Tanning Process. Journal of the American Leather Chemists Association. 105(6):181-8.
Musa, A. E., Madhan, B.*, Madhulatha, W., Rao, J.R., Sadulla, S., and Gasmelseed, G. A. (2009) Coloring of Leather using Henna - Natural Alternative Material for Dyeing, Journal of the American Leather Chemists Association 104, 183-190.
Musa, A.E., Madhan, B., Aravind, R., Rao, J.R., Chandrasekaran, B, Gasmelseed, G.A. (2009) Studies on Combination Tanning based on Henna and Oxazolidine Journal of the American Leather Chemists Association 104, 335-343.
Kanth, S. V., Venba, R., Madhan, B., Chandrababu, N. K. and Sadulla, S. (2009) Cleaner tanning practices for tannery pollution abatement: Role of enzymes in eco-friendly vegetable tanning. Journal of Cleaner Production 17, 507-515.
Aravindhan R, Madhan B, Thanikaivelan P, Kanth SV, Rao JR, Gnanasekaran CS. (2008) Upgradation of leathers: Masking defects using pigments in pre-finishing processes. Journal of Scientific & Industrial Research. Mar;67(3):233-8.
Madhan, B., Xiao, J. X., Thiagarajan, G., Baum, J., and Brodsky, B. (2008) NMR monitoring of chain-specific stability in heterotrimeric collagen peptides, Journal of the American Chemical Society 130, 13520-13521.
Bodian, D. L., Madhan, B., Brodsky, B., and Klein, T. E. (2008) Predicting the clinical lethality of osteogenesis imperfecta from collagen glycine mutations, Biochemistry 47, 5424-5432.
Brodsky, B., Thiagarajan, G., Madhan, B., and Kar, K. (2008) Triple-helical peptides: An approach to collagen conformation, stability, and self-association, Biopolymers 89, 345-353.
Krishnamoorthy, G., Madhan, B, Sadulla, S., Rao, J. R., and Madhulatha, W. (2008) Stabilization of collagen by the plant polyphenolics Acacia mollissima and Terminalia chebula, Journal of Applied Polymer Science 108, 199-205.
Kanth, S. V., Venba, R., Madhan, B., Chandrababu, N. K., and Sadulla, S. (2008) Studies on the influence of bacterial collagenase in leather dyeing, Dyes and Pigments 76, 338-347.
Madhan, B.*, Balaji, G., Aravindhan, R., Kanth, S. V., Sadulla, S., and Rao, J. R. (2008) Glove leather manufacture from sheepskins: Influence of fatliquors and syntans on the gloving properties, Journal of the American Leather Chemists Association 103, 182-190.
Musa, A. E., Madhan, B.*, Madhulatha, W., Sadulla, S., and Gasmelseed, G. A. (2008) Henna extract: Can it be alternative retanning agent?, Journal of the American Leather Chemists Association 103, 188-193.
Madhan, B., Aravindhan, R., Ranjithakumar, N., Venkiah, V., Rao, J. R., and Nair, B. U. (2007) Combination tanning based on Tara: An attempt to make chrome-free garment leathers, Journal of the American Leather Chemists Association 102, 198-204.
Kanth, S. V., Ipe, A., Madhan, B., Venba, R., and Dhathathreyan, A. (2007) Effect of different retanning systems on surface properties of leather, Journal of the American Leather Chemists Association 102, 135-142.
Madhan, B., Krishnamoorthy, G., Rao, J. R., and Nair, B. U. (2007) Role of green tea polyphenols in the inhibition of collagenolytic activity by collagenase, International Journal of Biological Macromolecules 41, 16-22.
Kanth, S. V., Madhan, B., Philo, M. J., Mithuna, S., Rao, J. R., and Nair, B. U. (2007) Tanning with natural polymeric materials - Part I: Ecofriendly tanning using dialdehyde sodium alginate, Journal of the Society of Leather Technologists and Chemists 91, 252-259.
Kanth, S. V., Nirenjana, M., Archana, T. N., Madhan, B., Rao, J. R., and Nair, B. U. (2007) Dialdehyde alginic acid - A novel biopolymeric tanning agent, Journal of the American Leather Chemists Association 102, 353-361.
Madhan, B., Aravindhan, R., Siva, M. S., Sadulla, S., Rao, J. R., and Nair, B. U. (2006) Interaction of aluminum and hydrolysable tannin polyphenols: An approach to understand the mechanism of aluminum vegetable combination tannage, Journal of the American Leather Chemists Association 101, 317-323.
Kanth, S. V., Venba, R., Madhan, B., Jawahar, M., Chitra, P., Yasothai, A., Chandrababu, N. K., and Sadulla, S. (2006) Studies on the influence of proteolytic enzymes in leather dyeing, Journal of the American Leather Chemists Association 101, 435-443.
Kanth, S. V., Madhan, B., Rao, J. R., Nair, B. U., Sadulla, S., and Ramasami, T. (2006) Studies on the stabilization of collagen using dialdehyde starch: Part I. Effect of autoclaving on dialdehyde starch, Journal of the American Leather Chemists Association 101, 444-453.
Madhan, B., Sreeram, K. J., Sharli, A., Rao, J. R., and Nair, B. U. (2005) An integrated approach for the treatment of vegetable tanning wastewaters, Journal of the Society of Leather Technologists and Chemists 89, 9-14.
Madhan, B., Narasimman, R., Gunasekaran, S., Sadulla, S., and Rao, J. R. (2005) Integrated chrome free upper leather processing - Part I: Selection of tanning system, Journal of the American Leather Chemists Association 100, 282-290.
Madhan, B., Gunasekaran, S., Narasimman, R., Rao, J. R., and Sadulla, S. (2005) Integrated chrome free upper leather processing - Part-II: Standardization and evaluation of vegetable-aluminium tanning system, Journal of the American Leather Chemists Association 100, 373-379.
Madhan, B., Subramanian, V., Rao, J. R., Nair, B. U., and Ramasami, T. (2005) Stabilization of collagen using plant polyphenol: Role of catechin, International Journal of Biological Macromolecules 37, 47-53.
Fathima, N. N., Madhan, B., Rao, J. R., Nair, B. U., and Ramasami, T. (2004) Interaction of aldehydes with collagen: effect on thermal, enzymatic and conformational stability, International Journal of Biological Macromolecules 34, 241-247.
Madhan, B., Rao, J. R., Subramanian, V., Nair, B. U., and Ramasami, T. (2004) Role of phenolics in the stabilization of collagen, Journal of the American Leather Chemists Association 99, 157-163.
Aravindhan, R., Madhan, B., Rao, J. R., Nair, B. U., and Ramasami, T. (2004) Bioaccumulation of chromium from tannery wastewater: An approach for chrome recovery and reuse, Environmental Science & Technology 38, 300-306.
Aravindhan, R., Madhan, B., Rao, J. R., and Nair, B. U. (2004) Recovery and reuse of chromium from tannery wastewaters using Turbinaria ornata seaweed, Journal of Chemical Technology and Biotechnology 79, 1251-1258.
Aravindhan, R., Madhan, B., Rao, J. R., and Nair, B. U. (2004) Bioaccumulation route for secured recovery and recoup of chromium from tannery wastewaters, Journal of the American Leather Chemists Association 99, 197-204.
Fathima, N. N., Madhan, B., Rao, J. R., and Nair, B. U. (2003) Effect of zirconium(IV) complexes on the thermal and enzymatic stability of type I collagen, Journal of Inorganic Biochemistry 95, 47-54.
Sundarrajan, A., Madhan, B., Rao, J. R., and Nair, B. U. (2003) Studies on tanning with zirconium oxychloride: Part I standardization of tanning process, Journal of the American Leather Chemists Association 98, 101-106.
Madhan, B., Sundarrajan, A., Rao, J. R., and Nair, B. U. (2003) Studies on tanning with zirconium oxychloride: Part II development of a versatile tanning system, Journal of the American Leather Chemists Association 98, 107-114.
Fathima, N. N., Madhan, B., Rao, J. R., and Nair, B. U. (2003) Mixed metal tanning using chrome-zinc-silica: A new chrome-saver approach, Journal of the American Leather Chemists Association 98, 139-146.
Madhan, B., Fathima, N. N., Rao, J. R., Subramanian, V., Nair, B. U., and Ramasami, T. (2003) Hydration in matrix stabilization of collagen fibres: Relevance to mechanistic insight into tanning, Journal of the American Leather Chemists Association 98, 263-272.
Madhan, B., Subramanian, V., Rao, J. R., Nair, B. U., and Ramasami, T. (2003) A semi-empirical quantum mechanical modeling study on the interaction of collagen-like peptides with polyphenolic molecules: An attempt to gain insights into vegetable tanning, Journal of the American Leather Chemists Association 98, 273-278.
Madhan, B., Fathima, N. N., Rao, J. R., and Nair, B. U. (2003) Molecular level understanding of tanning using an organo-zirconiuum complex, Journal of the American Leather Chemists Association 98, 445-450.
Parthasarathi, R., Madhan, B., Subramanian, V., and Ramasami, T. (2003) Ab initio and density functional theory based studies on collagen triplets, Theoretical Chemistry Accounts 110, 19-27.
Sharli, A., Madhan, B., Rao, J. R., and Nair, B. U. (2003) An approach for the treatment of vegetable tan liquor containing hydrolysable tannins, Journal of the American Leather Chemists Association 98, 381-387.
Madhan, B., Parthasarathi, R., Subramanian, V., Rao, J. R., Nair, B. U., and Ramasami, T. (2003) Density functional theory calculations on dipeptide-gallic acid interaction, Chemical Physics Letters 369, 131-138.
Madhan, B., Muralidharan, C., and Jayakumar, R. (2002) Study on the stabilisation of collagen with vegetable tannins in the presence of acrylic polymer, Biomaterials 23, 2841-2847.
Madhan, B., Fathima, N. N., Rao, J. R., and Nair, B. U. (2002) New chromium-zinc tanning agent: A viable option for less chrome technology, Journal of the American Leather Chemists Association 97, 189-196.
Madhan, B., Jayakumar, R., Muralidharan, C., and Gnanasekaran, C. S. (2001) Improvements in vegetable tanning - Can acrylics be co-tanning agents?, Journal of the American Leather Chemists Association 96, 120-126.
Madhan, B., Rao, J. R., and Nair, B. U. (2001) Tanning agent based on mixed metal complexes of aluminium and zinc, Journal of the American Leather Chemists Association 96, 343-349.
Madhan, B., Thanikaivelan, P., Subramanian, V., Rao, J. R., Nair, B. U., and Ramasami, T. (2001) Molecular mechanics and dynamics studies on the interaction of gallic acid with collagen-like peptides, Chemical Physics Letters 346, 334-340.

List of National Publications

B. Madhan, V. John Sundar, C. Muralidharan and C.S. Gnanasekaran, “ Vegetable Acrylic Combination Tanning – An Emerging Option for Mineral Free Tanning”, J. Ind. Leather Tech. Ass., December 2000, N0. 12, 713-721.
B Madhan, Aruna Dhathathreyan, V Subramanian and T Ramasami “Investigations on geometrical features in induced ordering of collagen by small molecules”, Proc. Ind. Aca. Sci. 2003, 115, 751-766.
R. Aravindhan, B. Madhan, P. Thanikaivelan, S.V. Kanth, J. Raghava Rao and B.U. Nair. “Upgradation of leathers: Masking defects in pre-finishing processes”, J. Sci. Ind. Res. 2008, 67, 233-238.

List of Patents

M Dinesh Kumar, K R Ramya, B Madhan, P Saravanan. A new process for the preparation of high value materials from raw hides and skin trimmings. (Cleared by SCIM)
Novel acrylic grafted keratin hydrolysate copolymer for industrial applications and a process for the preparation thereof (212NF2016; 201611038898)
G. Arun, N. Vedaraman, B. Madhan, J. Raghava Rao. A process for the preservation of hide and/or skin (201611002827)
M. Sathish, K. J. Sreeram, B. Madhan, J. Raghava Rao, B.C. Unni Nair. An improved tanning process (2704DEL2014).
M. Sathish, B. Madhan, J. Raghava Rao, B.C. Unni Nair. A novel retanning agent and a process for the preparation thereof (2509DEL2014).
M Ami, G C Jayakumar, N Nishad Fathima, B. Madhan, J Raghava Rao, B.C. Unni Nair A process for fibre opening in leather making (1005DEL2014).
S. K. Ramadass, P. Sathiamurthi, B. Madhan, S. Ganesh. A novel collagen hydrolysate sponge scaffold and a process for the preparation thereof (15Del2014)
V. Natarajan, N. Krithica, B. Madhan, A.B. Mandal. A novel collagen based biomaterial for drug delivery and tissue engineering and a process for the preparation thereof (0422DEL2014).

List of Conferences

Fourth international Conference on Natural polymers and Biomaterials-ICNP, Kottayam, 10-12 April 2015.
Fabrication of Keratin composite scaffolds for biomedical applications. Prachi K, Madhan B, Ganesh S. International Conference on Polymeric Biomaterials, Bioengineering and Biodiagnostics 'Biomaterials-2014' held in New Delhi, 27-30 October, 2014
Sol-gel assisted preparation of collagen hydrolysate scaffold: A Novel biomaterial for the treatment of chronic wounds. Ramadass SK, Perumal S and Madhan B. 26th Annual Conference – European Society of Biomaterials held in Liverpool, UK, 31st Aug – 3rd Sep 2014
Mesalamine collagen in situ rectal gel: A synergistic therapy for treating ulcerative colitis. Ramadass SK, Perumal S, Jabaris SL, Madhan B. International Conference on Medical Materials, Devices and Regenerative Medicine held in Kathmandu, Nepal, 11-14th January 2014.
Preparation and Characterisation of Mupirocin Incorporated Silica Microspheres Loaded 3D Collagen Scaffold. Perumal S, Ramadass SK, Madhan B. International Conference on Medical Materials, Devices and Regenerative Medicine held in Kathmandu, Nepal, 11-14th January 2014.
Collagen in ethanol – What happens to the triple helix? Arun G, Reddy SMM, Ganesh S, Madhan B, Rao JRR. International Conference on Medical Materials, Devices and Regenerative Medicine held in Kathmandu, Nepal, 11-14th January 2014.
Injectable polycaprolactone carriers for controlled and targeted delivery of quercetin in tumor sites” Natarajan V, Madhan B. International Conference on Medical Materials, Devices and Regenerative Medicine held in Kathmandu, Nepal, 11-14th January 2014.
Quercetin nanoparticles loaded Collagen scaffold: Implants for tissue reconstruction after mastectomy of cancerous breast. V Natarajan, Chandan Kumar Reddy, A Tamil Selvi and B Madhan. SETCOR International Conference on Nanotechnology Dubai, 28 – 30 October, 2013.
Combination tanning based on Tara and THPS: A new chrome free tanning system. B. Madhan, R. Aravindhan, T. Senthil Raja and J. Raghava Rao. XXXI IULTCS Congress, Valencia, Spain, 27-30 September, 2011.
Crystal strcuture of collagen peptide modeling Osteogenesis Imperfecta (O. I) mutation. S. M. Jaimohan, B. Madhan, M. D. Naresh, A. B. Mandal, B. Brodsky, K. Okuyama. International Symposium on Recent Trends in Macro molecular Structure and Function, p.31, Chennai, 2010.
Participated in 2008 Science Meeting, New Types and New Approaches to OI, Chicago, IL, USA, 27-29 April, 2008.
Participated in 5th Annual New Jersey Biomedical Engineering Showcase, Rutgers University, New Jersey, USA, 14th March, 2008.
Geometric Factors in Collagen-Polyphenol interactions: A Host-Guest Interaction of Value. B. Madhan, R. Parthasarathi1, V. Subramanian and T. Ramasami. Gordon Research Conference(GRC) in Collagen, Colby-Sawyer College in New London, New Hampshire, USA, 22 - 27 July 2007.
Biodegradable leathers: Role of biopolymers as tanning agents. S. V. Kanth, B. Madhan, P. Saravanan, J. R. Rao, B. U. Nair. Visual Display in XXIX Congress of the IULTCS and the 103rd annual convention of the American Leather Chemists Association, 20-24 June, 2007, Washington, DC, USA.
Participated in Spotlight on Skin Research, June 25, 2007, Hosted by the New Jersey Center for Biomaterials, Piscataway, NJ.
Stabilization of Collagen using Dialdehyde Alginic Acid - an Ecofriendly Tanning System; M.Nirenjana, T.N. Archana, S. V. Kanth, B. Madhan, J. R. Rao, B. U. Nair, S. Sadulla, T Ramasami. Visual Display in IULTCS II-EUROCONGRESS, Istanbul, May 2006.
Influence of proteolytic enzymes in leather dyeing. S. V. Kanth, R. Venba, B. Madhan, M. Jawahar, N.K. Chandrababu, S. Sadulla. Paper presented at CLRI on 26th September 2005 organized as a part of CSIR foundation day celebrations.
Eco-friendly dyeing of leather: Role of acid protease. G.C.Jaya Kumar, T.E.Rajkumar, G.Sankar, S. V. Kanth, R. Venba, B. Madhan, N.K. Chandrababu, S. Sadulla. Paper presented at CHEMCON conference, IIT Guwahati, 7-9th December 2005.
An Eco-Friendly Tanning System for Leather. M.Nirenjana, T.N. Archana, S.V. Kanth, B Madhan, J. R. Rao, B. U. Nair, S. Sadulla, T Ramasami. Paper presented at CHEMCON conference, IIT, Gawahati, 7-9th December 2005. (The paper won Best Paper Award – 1st Prize).
Interaction of Aldehydes with Collagen: Effect on Thermal, Enzymatic and Conformational Stability. B. Madhan, N. Nishad Fathima, J. Raghava Rao and B. U. Nair. Paper presented at the young scientist seminar of 91st Indian Science Congress Association, Punjab University, Chandigarh, January 3-7, 2004.
The Interaction of Zirconium Complexes with Collagen: Effect on Thermal and Enzymatic Stability. N Nishad Fathima, B Madhan, J Raghava Rao, B U Nair. Paper presented at seminar on ‘Innovation in Leather Science and Technology’, CLRI, Chennai, April 24, 2003
Hartree-Fock and density functional theory calculation on the stability of collagen triplet sequences. B. Madhan, R. Parthasarathi, V. Subramanian and T. Ramasami. Presented at 5th National Symposium in Chemistry under the aegis of Chemical Research Society of India, Chennai, 7-9 Feb, p.70, 2003
Molecular dynamics of collagen-like peptides. R. Parthasarathi, B. Madhan, V. Subramanian and T. Ramasami. Presented at 5th National Symposium in Chemistry under the aegis of Chemical Research Society of India, Chennai, 7-9 Feb, p.69, 2003
Effect of zirconium(IV) complexes on the thermal and enzymatic stability of type I collagen (Selected for best poster award). N Nishad Fathima, B Madhan, J Raghava Rao and Balachandran Unni Nair. Presented at 5th National Symposium in Chemistry under the aegis of Chemical Research Society of India, Chennai, 7-9 Feb, p.60, 2003.
Presented a poster in National Symposium in Chemistry Organized by Chemical Research Society of India at National Chemical Laboratory, Pune, Feb 1 – 3, 2002.
Presented a poster in Discussion Meeting On Structural Biology and Symposium On Biophysics, Organized by Dept. of Crystallography and Biophysics in association with Indian Biophysical Society, University of Madras, Guindy campus, Chennai, January 21-23, 2002.

Invited Lectures

Presentation on “Collagen based Composite Biomaterials to Manage Wound Pathogens and Chronic Wounds”, UK-India Workshop on Tackling the emergence of antimicrobial resistance, CSIR-IMtech Chandigarh, 7 – 10 Nov 2016
Invited lecture “Challenges and Opportunities in Leather Sector” at Ethiopian Institute of Fashion and Textile Technology, Bahirdhar University, 13-15th May 2016
Invited lecture on “Collagen: A Smart Material for Biomedical Applications”, Fourth international Conference on Natural polymers and Biomaterials-ICNP, Kottayam, 10-12 April 2015
Invited lecture on “Collagen Composite Scaffolds and Hydrogels for Biomedical Applications”, International Conference on Medical Materials, Devices and Regenerative Medicine- MMDRM, Kathmandu, (11-14 January 2014).
Presentation on “Stabilization of Collagen: Applications from Leather to Biomedical Engineering”, Annual Convention of Indian National Academy of Engineers held at Defence Metallurgical Research Laboratory (DMRL), Kanchanbagh, Hyderabad, 23rd December 2012.
Invited Lecture on “Drug Delivery Applications – For & From ‘Collagen’” as a part of Pharmacy Week Celebrations of The Tamilnadu Dr.MGR Medical University, 24th Nov 2012
Presentations on “Global Leather Trade” and “Indian Leather Sector: History and Growth” delivered to Prime Minister Office, Addis Ababa, Ethiopia. Meeting chaired by His Excellency Arkebe, Minister and Advisor to Prime Minister of Ethiopia, 25th June 2012
Presentation on “Research Initiatives for Waterless Tanning” Delivered to Research Council Meeting of CSIR-CLRI, 16th August 2012
Presented a lecture on “Cleaner Technologies in Leather Manufacture” at the Indo-Ethiopian Workshop on “Leather Trends, Product Design & Quality Assurance” held during 21-22 June 2012, Hotel Desalegn, Addis Ababa, Ethiopia
Presentation on “Stability and Stabilization of Collagen: Applications in Leather and Biomedical” – Science Club, 10th March 2012
Lecture on “Chrome Free Tanning Technologies”, delivered at Leather Industry Development Institute, Addis Ababa, Ethiopia, 2nd November 2011.
Lecture on “Drug Delivery Application using Collagen Matrices” delivered at B.L.Miad college of pharmacy, September 2011
Presentation on “Benchmarking(Technology Upgradation) Programme for Ethiopian Tanning Industries -A compilation on the gap analysis and action plan”, delivered to the Steering Committee meeting, Benchmarking Project, 3rd June 2010, Session Chaired by, His Excellency Girma Biru, Minister for Trade and Industry, Ethiopia
Lecture on “Stability and Stabilization of Collagen” delivered at National Metallurgical Laboratory of CSIR, Chennai, Nov, 2009.
Presentation on “Structural Studies on Collagen peptides: Their Role in understanding Osteogenesis Imperfecta”, delivered to the Research Council Meeting of CSIR-CLRI, April 2009
Presentation on “OI mutations: Effect of different residues replacing Glycine”, Department of Biochemistry, UMDNJ, Piscataway, Feb 2008
Presentation on “Studies on Collagen triple helix with Mutations”, Department of Biochemistry, UMDNJ, Piscataway, Nov 2007

List of Citations

B. Madhan , C. Muralidharan, R. Jayakumar and C.S. Gnanasekaran, “Improvements in Vegetable Tanning: Can Acrylics be Co-tanning Agents”, J. Amer. Leather Chem. Ass . , 2001, 96 , 121-127.
1	Sustaining tanning process through conservation, recovery and better utilization of chromium Resources, Conservation and Recycling, Volume 38, Issue 3, June 2003, Pages 185-212 K. J. Sreeram and T. Ramasami
2	Natural Leathers from Natural Materials: Progressing toward a New Arena in Leather Processing Environmental Science and Technology 38 (3) , 871-879, 2004 Saravanabhavan, S., Thanikaivelan, P., Rao, J.R., Nair, B.U., Ramasami, T.,

B. Madhan , J. Raghava Rao and B.U. Nair “Tanning Agent Based on Mixed Metal Complexes of Aluminium and Zinc”, J. Amer. Leather Chem. Ass . , 2001, 96 , 343-349.
1	Combination tannage of tannic acid and rare earth Journal of the Society of Leather Technologies and Chemists 88 (2), 72-75, 2004. Zhihua, S., Guowei, W.

B. Madhan , P. Thanikaivelan, V. Subramanian, J. Raghava Rao, B.U. Nair and T. Ramasami, “Molecular Mechanics and Dynamics Studies on the Interaction of Gallic Acid with Collagen like Peptides”, Chem. Phys. Lett. , 2001, 346 , 334-340.
1	Understanding the structural and binding properties of collagen: A theoretical perspective Journal of Physical Chemistry B 108 (28) , 10101-10112, 2004 Bronco, S., Cappelli, C., Monti, S.
2	Prediction of aqueous solubility of organic salts of diclofenac using PLS and molecular modeling International Journal of Pharmaceutics, Volume 275, Issues 1-2, 4 May 2004, Pages 133-139 Vimon Tantishaiyakul
3	Xing, F., Cheng, G., Yang, B., Ma, L. Microencapsulation of capsaicin by the complex coacervation of gelatin, acacia and tannins, Journal of Applied Polymer Science 91 (4) , 2669-2675, 2004

B. Madhan , C. Muralidharan and R. Jayakumar, “Study on the Stabilization of Collagen with Vegetable Tannins in the Presence of Acrylic Polymer”, Biomaterials , 2002, 23(14) , 2841 – 2847.
1	Understanding the structural and binding properties of collagen: A theoretical perspective Journal of Physical Chemistry B 108 (28) , 10101-10112, 2004 Bronco, S., Cappelli, C., Monti, S.
2	Development of collagenase-resistant collagen and its interaction with adult human dermal fibroblasts Biomaterials, Volume 24, Issue 28, December 2003, Pages 5099-5113 Hyun Chul Goo, Yu-Shik Hwang, Yon Rak Choi, Hyun Nam Cho and Hwal Suh
3	Microencapsulation of capsaicin by the complex coacervation of gelatin, acacia and tannins Journal of Applied Polymer Science 91 (4) , 2669-2675, 2004 Xing, F., Cheng, G., Yang, B., Ma, L.

B. Madhan , N. Nishad Fathima, J. R. Rao and B.U. Nair, “A New Chromium – Zinc Tanning Agent: A Viable Option for Less Chrome Technology”, J. Amer. Leather Chem. Ass ., 2002, 97(4) , 189 – 196.
1	Modified thrublu chrome tanning for lambskins: Low residual - Chrome tannages Journal of the Society of Leather Technologies and Chemists 88 (3) , 116-120, 2004 Dasgupta, S

B Madhan , R.Parthasarathi, V Subramanian, J Raghava Rao, B U Nair, T Ramasami, “ Ab Initio and Density Functional Calculations on Dipeptide-Gallic acid Interaction”, Chem. Phys. Lett. , 369, (2003) 131-138.
1	Understanding the structural and binding properties of collagen: A theoretical perspective Journal of Physical Chemistry B 108 (28) , 10101-10112, 2004 Bronco, S., Cappelli, C., Monti, S.


B Madhan , N Nishad Fathima, J Raghava Rao, V Subramanian, B U Nair and T Ramasami , “ Hydration In Matrix Stabilization Of Collagen Fibres: Relevance To Mechanistic Insight Into Tanning”, J. Amer. Leather Chem. Ass., 2003, 98 , 262 - 271.
1	Understanding the structural and binding properties of collagen: A theoretical perspective Journal of Physical Chemistry B 108 (28) , 10101-10112, 2004 Bronco, S., Cappelli, C., Monti, S.
2	Life Cycle Assessment as a Tool for the Environmental Improvement of the Tannery Industry in Developing Countries Environmental Science and Technology 38 (6) , 1901-1909, 2004. Rivela, B., Moreira, M.T., Bornhardt, C., Méndez, R., Feijoo, G.

N. Nishad Fathima, B. Madhan , J. Raghava Rao and Balachandran Unni Nair, “ Mixed metal tanning using Chrome–Zinc–Silica: A new chrome-saver approach”, J. Amer. Leather Chem. Ass ., 2003, 98 , 139-146.
1	Modified thrublu chrome tanning for lambskins: Low residual - Chrome tannages Journal of the Society of Leather Technologies and Chemists 88 (3) , 116-120, 2004 Dasgupta, S.

N. Nishad Fathima , B. Madhan , J. Raghava Rao and Balachandran Unni Nair, “ Effect of zirconium(IV) complexes on the thermal and enzymatic stability of type I collagen” J. Inorg. Biochem ., 2003, 95 , 47-54 .
1	Response to Comments by Hussein M. A. Al-Maydama on "The effect of UV radiation on the thermal parameters of collagen degradation" by Kaminska A 1 and Sionkowska A (Polym Degrad Stab 1996;51:15–18) Polymer Degradation and Stability, Volume 84, Issue 2, May 2004, Pages 367-368 Alina Sionkowska

R Parthasarathi, B Madhan , V Subramanian and T Ramasami, “ Ab Initio and Density Functional Theory based Perspectives on the Stability of Collagen Triplet Sequences”, Theo. Chem. Acc. , 2003, 110 , 19-27 .


B Madhan , V. Subramanian, J.R. Rao and T. Ramasami, “A Semi-empirical Quantum Mechanical Modeling Study on the Interaction of Collagen-like Peptides with Polyphenolic Molecules: An attempt to gain insights into vegetable tanning”, J. Amer. Leather Chem. Ass ., 2003, 98, 273-278.
1	Bronco, S., Cappelli, C., Monti, S. Understanding the structural and binding properties of collagen: A theoretical perspective Journal of Physical Chemistry B 108 (28) , 10101-10112, 2004
2	ThomasBredow, KarlJug Theory and range of modern semiempirical molecular orbital methods Theor Chem Acc(2005)113:1–14

B Madhan , Aruna Dhathathreyan, V Subramanian and T Ramasami “Investigations on geometrical features in induced ordering of collagen by small molecules”, Proc. Ind. Aca. Sci. 2003 , 115 , 751-766 .
1	Bronco, S., Cappelli, C., Monti, S. Understanding the structural and binding properties of collagen: A theoretical perspective Journal of Physical Chemistry B 108 (28) , 10101-10112, 2004
2	Tatsiana Shutava, Malcolm Prouty, Dinesh Kommireddy, and Yuri Lvov pH Responsive Decomposable Layer-by-Layer Nanofilms and Capsules on the Basis of Tannic Acid Macromolecules, ASAP Article 10.1021/ma047629x S0024-9297(04)07629-6 Web Release Date: March 2, 2005
3	J. Kaal, K.G.J. Nierop and J.M. Verstraten Retention of tannic acid and condensed tannin by Fe-oxide-coated quartz sand Journal of Colloid and Interface Science , Volume 287, Issue 1, 1 July 2005 , Pages 72-79
4	P. Rajalalitha, S. Vali Molecular pathogenesis of oral submucous fibrosis a collagen metabolic disorder Journal of Oral Pathology and Medicine Volume 34, Issue 6, Page 321-328, Jul 2005

R Aravindhan , B Madhan , J Raghava Rao and B U Nair, “ Bioaccumulation of chromium from tannery wastewater: an approach for chrome recovery and reuse ”, Env. Sci. Tech. , 2004, 38, 300-306
1	Biosorption of cesium by native and chemically modified biomass of marine algae: introduce the new biosorbents for biotechnology applications Journal of Hazardous Materials, Volume 116, Issues 1-2, 10 December 2004 , Pages 125-134 R. Jalali-Rad, H. Ghafourian, Y. Asef, S.T. Dalir, M.H. Sahafipour and B.M. Gharanjik

S No	Period	Place	Designation
1	May 2002-May 2005	CSIR-CLRI, Chennai	Scientist B
2	May 2005-May 2008	CSIR-CLRI, Chennai	Scientist C
3	May 2007-May 2008	Robert Wood Johnson Medical School, UMDNJ (Rutgers), New Jersey	Post-Doc Researcher
4	May 2008-May 2012	CSIR-CLRI, Chennai	Senior Scientist
5	May 2012-May 2017	CSIR-CLRI, Chennai	Principal Scientist
6	May 2017-Till Date	CSIR-CLRI, Chennai	Senior Principal Scientist

S No	Period of visit		Institute/ country visited	Purpose of visit
	From	To	Institute/ country visited	Purpose of visit
1	May 2007	May 2008	Robert Wood Johnson Med School (UMDNJ, RUTGERS), USA	Research
2	Mar 2010	Sep 2010	Ethiopia	Consultancy Project on “Benchmarking Technology Upgradation of Tanneries”
3	26-09-2011	30-09-2011	Valencia, Spain	IULTCS Conference
4	13-07-2013	21-07-2013	Colby Sawyer College, New Hampshire, USA	Gordon Research Conference on Collagen
5	17-06-2014	20-06-2014	Harare, Zimbabwe	COMESA LLPI Meeting
6	13-07-2016	22-07-2016	Vietnam	Leather Fair
7	20-09-2016	23-09-2016	Israel	As an expert to review the technology for treatment of tannery wastewater
8	19-02-2017	21-02-2017	National Industrial Research & Development Agency (NIRDA), Rwanda	Indo-Rwanda Innovation Growth Programme
9	22-08-2017	26-08-2017
10	10-06-2018	15-06-2018
11	15-10-2019	28-10-2019		Consultancy Project on “Leather Value Chain Development in Rwanda”
12	18-04-2017	18-05-2017	Kenyan Industrial Research & Development Agency, Kenya	Consultancy Project on “Kenyan Leather Development Programme”
13	2011	2019	Several Visits to Leather Industry Development Institute (LIDI), Ethiopia	Consultancy Project on Capacity Building of LIDI

Project	Role	Grant (in lakhs)	Duration	Sponsor Agency	Achievements
Stabilization of Collagen: Applications in Biomedical Engineering and Arthritis Management	Principal Investigator	25	Jan 2010-Dec 2014	CSIR	2 Collagen Bio- materials developed; 1 Patent, 5 Publications;
Molecules to Materials to Diagnostics (XIIFYP Network Project)	Principal Investigator	75	Oct. 2012 to March 2017	CSIR	1Bio-material based on collagen hydrolysate,1 Bio- material based on Collagen-Mupirocin developed, 1 Patent, 4 publications, 1 Technology transfer.
Research Initiatives For Waterless Tanning (XII Five Year Plan Project)	Co-Principal Investigator	400	Oct. 2012 to March 2017	CSIR	Publications-15 Patents –6 Technology transferred to 60 tanneries
“Pharmaceutical grade gelatin manufacture from hide trimmings” under the network project “Zero Research Initiatives for Solid Wastes from Leather” XII Five Year Plan Project	Work Package Leader	10	Oct. 2012 to March 2017	CSIR	2 Patents 3 Publications
Fast Track Translation project on “High value products from Raw Trimmings”	Principal Investigator	12	April 2017 to March 2018	CSIR	1 Technology transfer
High Value Products from Hides & Skins	Principal Investigator	25	Sep 2018 (On going)	CSIR	1 Biomaterial developed from goat skin

S. No.	Name	Title (University)	Status
1	Natarajan V	Collagen Crosslinking in Biomaterial Development and Arthritis Management (Anna University)	Completed
2	Satiesh Kumar R	Sol-Gel Assisted Collagen / Collagen Hydrolysate based Therapeutics for Biomedical Application (Anna University)	Completed
3	Prachi Kakkar	Utilization of Keratin from Solid Bio-waste for Biomedical Applications (Anna University)	Completed
4	Shegaw Ahmed Mohammed	Studies on the Application of Ethiopian Plant Species of Mekmeko (Rumex abyssinicus) in Leather Processing	Completed
5	Sathiamurthy	Collagen Based Bio-Material for Unmet Clinical Applications (ACSIR)	Completed
6	Sathish Kumar. K	Studies in drug delivery system using collagen in-situ gel (Sri Ramachandra University)	Ongoing
7	Arun G	Collagen-Hydroxyapatite-Collagen Peptide Composite Scaffolds for Hard Tissue Regeneration (Anna University)	Ongoing
8	Dineshkumar M	Development of High Value Collagenous Product from Trimming Waste (Anna University)	Ongoing
9	Ramya K R	Preparation of high value products from animal hair waste (Anna University)	Ongoing
10	Naisini A	Studies on the utilization of super critical carbon-di-oxide for zero waste discharge leather manufacture	Ongoing
11	Vimudha	Bio-plastics from Tannery Waste	Ongoing

S. No.	Name	Sponsoring Agency	Status
1	Dr Ramesh Kannan	UGC Kothari Fellowship	Ongoing
2	Dr Thangam Ramar	DST SERB Fellowship	Completed
3	Dr Agnes Mary	DST SERB Fellowship	Ongoing
4	Dr Senthil Kumar	DST INSPIRE Faculty	Ongoing

S No

S No